LETROZOLE tablet, film coated

Even if you have had your menopause, your doctor will discuss using effective contraception during your treatment. Letrozole is usually used when you have been through a natural menopause. However, if you have recently been through the menopause or are having treatment to stop your ovaries working (temporary menopause), there is still a very small chance you may become pregnant.

Female infertility refers to not being able to become or stay pregnant. Infertility is often caused by problems with ovulation (when eggs are released from your ovaries). And ovulation problems commonly happen because of a condition called polycystic ovary syndrome (PCOS). Femara may be used off-label to treat infertility due to PCOS and other causes. Although allergic reaction wasn’t reported in studies of Femara, it can still happen.

• Selected baseline characteristics for this study are shown in Table 11.
• Calcium, in particular, is better to get from your diet than from supplements whenever possible.
• If side effects cannot be managed, your doctor may suggest a different type of hormonal therapy.

Adjuvant treatment of early breast cancer

It’s an aromatase inhibitor, which decreases the hormone estrogen by blocking a critical step in your body’s manufacture of estrogen. You can talk to your cancer team if you want more detailed information about this treatment. Or visit the electronic Medicines Compendium (eMC) website, which has patient information leaflets (PIL) for individual drugs. Tell your doctor and pharmacist about all of your drugs Somatropin in USA (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems.

Blood tests may be needed to check for unwanted effects. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Letrozole may causeallergic reactions, which can be serious. Stop taking letrozole and get help right away if you have any of the following symptoms of a serious allergic reaction. Xeloda is used to treat breast and colorectal cancers.

Try to pace yourself and plan your day so you have time to rest between activities. This drug may interact with other drugs or health problems. Don’t breastfeed during this treatment because the drug may come through into your breast milk. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient.

Other Medical Problems

If you’re worried about a particular side effect, discuss ways it may be prevented or managed if it develops. By participating fully in the decision, you’ll feel more confident about your treatment plan. When asked which medication they preferred taking, about 30 percent of participants said they like letrozole better, and about 36 percent preferred anastrozole. The five-year DFS rates were 84.9 percent for letrozole and 82.9 percent for anastrozole. Even though DFS was slightly higher for participants taking letrozole, the difference wasn’t statistically significant. The overall survival rate was also similar for both groups, with 89.9 percent for participants receiving letrozole and 89.2 percent for those getting anastrozole.

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Patients with severe liver impairment should receive 2.5 mg every other day. Data from a small phase II study support the use of letrozole in the treatment of platinum- and taxane-resistant recurrent epithelial ovarian cancer Ramierz 2008. Additional trials may be necessary to further define the role of letrozole in this condition. This leads to inhibition of the enzyme and a significant reduction in plasma estrogen (estrone, estradiol and estrone sulfate) levels. Letrozole does not appear to affect synthesis of adrenal or thyroid hormones, aldosterone, or androgens. We use gender-inclusive language and talk to our readers as ‘you’ so that everyone feels included.